Assay Detail
Binding
CHEMBL1027390
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Inhibition of Toxoplasma gondii dihydrofolate reductase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.65 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493717 | — | — | 1 | 8.44 |
| CHEMBL521672 | — | — | 1 | 8.43 |
| CHEMBL32113 | — | — | 1 | 8.20 |
| CHEMBL523004 | — | — | 1 | 8.14 |
| CHEMBL493718 | — | — | 1 | 8.11 |
| CHEMBL492895 | — | — | 1 | 8.02 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL522678 | — | — | 1 | 7.92 |
| CHEMBL492896 | — | — | 1 | 7.72 |
| CHEMBL522543 | — | — | 1 | 7.72 |
| CHEMBL455012 | — | — | 1 | 7.60 |
| CHEMBL325434 | — | — | 1 | 7.52 |
| CHEMBL116816 | — | — | 1 | 6.80 |
| CHEMBL32708 | — | — | 1 | 6.51 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493717 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL521672 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL32113 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL523004 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL493718 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL492895 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL522678 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL492896 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL522543 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL455012 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL325434 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL116816 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL32708 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 2700.0 | nM | 5.57 |