Assay Detail
Binding
CHEMBL1027392
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Inhibition of Mycobacterium avium dihydrofolate reductase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.29 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521672 | — | — | 1 | 9.01 |
| CHEMBL493717 | — | — | 1 | 8.96 |
| CHEMBL522678 | — | — | 1 | 8.64 |
| CHEMBL493718 | — | — | 1 | 8.54 |
| CHEMBL492895 | — | — | 1 | 8.48 |
| CHEMBL492896 | — | — | 1 | 7.89 |
| CHEMBL522543 | — | — | 1 | 7.85 |
| CHEMBL523004 | — | — | 1 | 7.80 |
| CHEMBL455012 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521672 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL493717 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL522678 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL493718 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL492895 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL492896 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL522543 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL523004 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL455012 | — | IC50 | = | 34.0 | nM | 7.47 |