Assay Detail
Functional
CHEMBL1027690
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Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.51 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499504 | — | — | 1 | 7.88 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.43 |
| CHEMBL499361 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499504 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL499361 | — | IC50 | = | 60.0 | nM | 7.22 |