Assay Detail
Functional
CHEMBL1027691
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Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BGC-823 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.07 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499361 | — | — | 1 | 6.24 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.06 |
| CHEMBL499504 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499361 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL499504 | — | IC50 | = | 1210.0 | nM | 5.92 |