Assay Detail
Binding
CHEMBL1027776
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Displacement of [3H]spiperone from wild type human cloned dopamine D4 receptor expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.31 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550222 | — | — | 1 | 9.20 |
| CHEMBL142020 | — | — | 1 | 8.70 |
| CHEMBL562620 | — | — | 1 | 8.64 |
| CHEMBL310843 | — | — | 1 | 8.17 |
| CHEMBL561763 | — | — | 1 | 7.92 |
| CHEMBL140612 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550222 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL142020 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL562620 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL310843 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL561763 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL140612 | — | Ki | = | 56.0 | nM | 7.25 |