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Assay Detail

CHEMBL1027883

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells after 48 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins.
Gauthier C, Legault J, Lavoie S, Rondeau S, Tremblay S, Pichette A.
J Nat Prod (2009) 72 : 72 -81
PubMed 19115839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.06 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44657 ETOPOSIDE 4.0 1 6.16
CHEMBL509430 1 5.77
CHEMBL509798 1 5.24
CHEMBL509927 1 5.22
CHEMBL444506 1 5.05
CHEMBL500006 1 5.02
CHEMBL507049 1 4.84
CHEMBL453268 1 4.70
CHEMBL503523 1 4.64
CHEMBL23236 BETULIN 1 4.63
CHEMBL269277 BETULINIC ACID 1.0 1 4.39
CHEMBL553343 1 -
CHEMBL501076 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44657 ETOPOSIDE IC50 = 700.0 nM 6.16
CHEMBL509430 IC50 = 1700.0 nM 5.77
CHEMBL509798 IC50 = 5700.0 nM 5.24
CHEMBL509927 IC50 = 6000.0 nM 5.22
CHEMBL444506 IC50 = 9000.0 nM 5.05
CHEMBL500006 IC50 = 9500.0 nM 5.02
CHEMBL507049 IC50 = 14500.0 nM 4.84
CHEMBL453268 IC50 = 20000.0 nM 4.70
CHEMBL503523 IC50 = 23000.0 nM 4.64
CHEMBL23236 BETULIN IC50 = 23300.0 nM 4.63
CHEMBL269277 BETULINIC ACID IC50 = 41000.0 nM 4.39
CHEMBL553343 IC50 > 100000.0 nM -
CHEMBL501076 IC50 > 100000.0 nM -