Assay Detail
Functional
CHEMBL1028057
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Inhibition of rhFGF2-induced HUVEC proliferation
9
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MEC | 6 | - | - |
| IC50 | 3 | 4.65 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231526 | — | — | 1 | 4.74 |
| CHEMBL480356 | — | — | 2 | 4.56 |
| CHEMBL274654 | ORANTINIB | 3.0 | 2 | - |
| CHEMBL481504 | — | — | 1 | - |
| CHEMBL511831 | — | — | 1 | - |
| CHEMBL470756 | — | — | 1 | - |
| CHEMBL472141 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231526 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL480356 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL274654 | ORANTINIB | MEC | = | 10.0 | uM | - |
| CHEMBL481504 | — | MEC | = | 50.0 | uM | - |
| CHEMBL511831 | — | MEC | = | 50.0 | uM | - |
| CHEMBL470756 | — | MEC | > | 50.0 | uM | - |
| CHEMBL472141 | — | MEC | = | 50.0 | uM | - |
| CHEMBL480356 | — | MEC | = | 10.0 | uM | - |
| CHEMBL274654 | ORANTINIB | IC50 | > | 50000.0 | nM | - |