Assay Detail
Binding
CHEMBL1028077
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Inhibition of IRK
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.94 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482169 | — | — | 1 | 7.29 |
| CHEMBL457886 | — | — | 1 | 6.82 |
| CHEMBL521241 | — | — | 1 | 6.62 |
| CHEMBL481379 | — | — | 1 | 6.42 |
| CHEMBL485202 | — | — | 1 | 6.25 |
| CHEMBL481380 | — | — | 1 | 6.20 |
| CHEMBL519116 | — | — | 1 | 5.80 |
| CHEMBL481720 | — | — | 1 | 5.70 |
| CHEMBL480754 | — | — | 1 | 5.62 |
| CHEMBL457706 | — | — | 1 | 5.42 |
| CHEMBL481884 | — | — | 1 | 5.28 |
| CHEMBL485203 | — | — | 1 | 5.25 |
| CHEMBL480373 | — | — | 1 | 5.24 |
| CHEMBL481369 | — | — | 1 | 5.21 |
| CHEMBL481360 | — | — | 1 | - |
| CHEMBL481900 | — | — | 1 | - |
| CHEMBL475593 | — | — | 1 | - |
| CHEMBL521113 | — | — | 1 | - |
| CHEMBL520110 | — | — | 1 | - |
| CHEMBL481738 | — | — | 1 | - |
| CHEMBL480753 | — | — | 1 | - |
| CHEMBL480592 | — | — | 1 | - |
| CHEMBL481901 | — | — | 1 | - |
| CHEMBL481567 | — | — | 1 | - |
| CHEMBL519960 | — | — | 1 | - |
| CHEMBL519927 | — | — | 1 | - |
| CHEMBL482367 | — | — | 1 | - |
| CHEMBL521432 | — | — | 1 | - |
| CHEMBL520432 | — | — | 1 | - |
| CHEMBL481559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482169 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL457886 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL521241 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL481379 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL485202 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL481380 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL519116 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL481720 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL480754 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL457706 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL481884 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL485203 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL480373 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL481369 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL480365 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481721 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481361 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481362 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL520768 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480374 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481370 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480547 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481378 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL458796 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480573 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480554 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480555 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480566 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480574 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL518937 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480592 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481559 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL520432 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL521432 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL482367 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL519927 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL519960 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481567 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481901 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL460824 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL480753 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481738 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL520110 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL521113 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL475593 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481900 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL481360 | — | IC50 | > | 6000.0 | nM | - |