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Assay Detail

CHEMBL1028089

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Binding
Inhibition of human recombinant geranylgeranyl diphosphate synthase
ChEMBL ↗
118
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Geranylgeranyl pyrophosphate synthase (CHEMBL4769) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E.
J Med Chem (2008) 51 : 5594 -5607
PubMed 18800762 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 118 5.43 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291314 — — 2 7.00
CHEMBL494694 — — 2 6.60
CHEMBL494897 — — 2 6.60
CHEMBL494896 — — 2 6.50
CHEMBL494898 — — 2 6.40
CHEMBL522337 — — 2 6.30
CHEMBL493443 — — 2 6.23
CHEMBL495485 — — 2 6.20
CHEMBL54004 — — 2 6.20
CHEMBL262616 — — 2 6.14
CHEMBL492621 — — 2 6.12
CHEMBL492622 — — 2 6.10
CHEMBL258994 DIGERANYL BISPHOSPHONATE — 2 6.01
CHEMBL494279 — — 2 5.94
CHEMBL238046 — — 2 5.91
CHEMBL495079 — — 2 5.90
CHEMBL237808 — — 2 5.83
CHEMBL494876 — — 2 5.80
CHEMBL494708 — — 2 5.73
CHEMBL493706 — — 2 5.70
CHEMBL213490 — — 2 5.70
CHEMBL524189 — — 2 5.63
CHEMBL493906 — — 2 5.60
CHEMBL522167 — — 2 5.60
CHEMBL495126 — — 2 5.60
CHEMBL259026 — — 2 5.60
CHEMBL416301 — — 2 5.60
CHEMBL495127 — — 2 5.52
CHEMBL235690 — — 2 5.50
CHEMBL260880 — — 2 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291314 — IC50 = 100.0 nM 7.00
CHEMBL291314 — IC50 = 100.0 nM 7.00
CHEMBL494897 — IC50 = 251.19 nM 6.60
CHEMBL494694 — IC50 = 251.19 nM 6.60
CHEMBL494694 — IC50 = 280.0 nM 6.55
CHEMBL494897 — IC50 = 280.0 nM 6.55
CHEMBL494896 — IC50 = 316.23 nM 6.50
CHEMBL494896 — IC50 = 350.0 nM 6.46
CHEMBL494898 — IC50 = 398.11 nM 6.40
CHEMBL494898 — IC50 = 400.0 nM 6.40
CHEMBL522337 — IC50 = 501.19 nM 6.30
CHEMBL522337 — IC50 = 510.0 nM 6.29
CHEMBL493443 — IC50 = 590.0 nM 6.23
CHEMBL493443 — IC50 = 630.96 nM 6.20
CHEMBL495485 — IC50 = 630.96 nM 6.20
CHEMBL54004 — IC50 = 630.96 nM 6.20
CHEMBL495485 — IC50 = 660.0 nM 6.18
CHEMBL54004 — IC50 = 710.0 nM 6.15
CHEMBL262616 — IC50 = 720.0 nM 6.14
CHEMBL492621 — IC50 = 760.0 nM 6.12
CHEMBL262616 — IC50 = 794.33 nM 6.10
CHEMBL492621 — IC50 = 794.33 nM 6.10
CHEMBL492622 — IC50 = 794.33 nM 6.10
CHEMBL492622 — IC50 = 890.0 nM 6.05
CHEMBL258994 DIGERANYL BISPHOSPHONATE IC50 = 980.0 nM 6.01
CHEMBL258994 DIGERANYL BISPHOSPHONATE IC50 = 1000.0 nM 6.00
CHEMBL494279 — IC50 = 1150.0 nM 5.94
CHEMBL238046 — IC50 = 1230.0 nM 5.91
CHEMBL494279 — IC50 = 1258.93 nM 5.90
CHEMBL238046 — IC50 = 1258.93 nM 5.90
CHEMBL495079 — IC50 = 1258.93 nM 5.90
CHEMBL495079 — IC50 = 1260.0 nM 5.90
CHEMBL237808 — IC50 = 1480.0 nM 5.83
CHEMBL237808 — IC50 = 1584.89 nM 5.80
CHEMBL494876 — IC50 = 1584.89 nM 5.80
CHEMBL494876 — IC50 = 1740.0 nM 5.76
CHEMBL494708 — IC50 = 1860.0 nM 5.73
CHEMBL493706 — IC50 = 1995.26 nM 5.70
CHEMBL213490 — IC50 = 1995.26 nM 5.70
CHEMBL494708 — IC50 = 1995.26 nM 5.70
CHEMBL493706 — IC50 = 2140.0 nM 5.67
CHEMBL213490 — IC50 = 2140.0 nM 5.67
CHEMBL524189 — IC50 = 2340.0 nM 5.63
CHEMBL522167 — IC50 = 2510.0 nM 5.60
CHEMBL416301 — IC50 = 2511.89 nM 5.60
CHEMBL259026 — IC50 = 2511.89 nM 5.60
CHEMBL495126 — IC50 = 2510.0 nM 5.60
CHEMBL495126 — IC50 = 2511.89 nM 5.60
CHEMBL493906 — IC50 = 2510.0 nM 5.60
CHEMBL524189 — IC50 = 2511.89 nM 5.60