Assay Detail
ADMET
CHEMBL1028101
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Cytotoxicity against HFF cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.96 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523859 | — | — | 1 | 5.38 |
| CHEMBL494060 | — | — | 1 | 5.31 |
| CHEMBL453510 | — | — | 1 | 5.15 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 4.79 |
| CHEMBL1794066 | GSK-619487A | — | 1 | 4.74 |
| CHEMBL494088 | — | — | 1 | 4.70 |
| CHEMBL521642 | — | — | 1 | 4.67 |
| CHEMBL493269 | — | — | 1 | - |
| CHEMBL522351 | — | — | 1 | - |
| CHEMBL1794065 | GSK-554170A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523859 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL494060 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL453510 | — | IC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL1794066 | GSK-619487A | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL494088 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL521642 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL493269 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL522351 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1794065 | GSK-554170A | IC50 | > | 30000.0 | nM | - |