Assay Detail
ADMET
CHEMBL1028183
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Cytotoxicity against PBL isolated from solid form of Graffi myeloid tumor bearing hamster pretreated at 0.5 mg/ml, ip for 5 days measured after 24 hrs by trypan blue assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetinae |
| Cell Type | PBL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.01 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450536 | — | — | 1 | 7.92 |
| CHEMBL503445 | — | — | 1 | 7.85 |
| CHEMBL455274 | — | — | 1 | 6.85 |
| CHEMBL472978 | — | — | 1 | 6.54 |
| CHEMBL447761 | — | — | 1 | 6.50 |
| CHEMBL451177 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450536 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL503445 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL455274 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL472978 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL447761 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL451177 | — | IC50 | = | 410.0 | nM | 6.39 |