Assay Detail
Binding
CHEMBL1028242
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Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.18 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241806 | TEPHROSIN | — | 1 | 6.96 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.82 |
| CHEMBL419669 | — | — | 1 | 6.72 |
| CHEMBL393417 | DEGUELIN | — | 1 | 6.66 |
| CHEMBL500257 | AMORPHASTILBOL | — | 1 | 6.58 |
| CHEMBL491820 | AMORFRUTIN A | — | 1 | 6.08 |
| CHEMBL494083 | XANTHOANGELOL | — | 1 | 5.99 |
| CHEMBL490809 | — | — | 1 | 5.95 |
| CHEMBL490810 | — | — | 1 | 5.81 |
| CHEMBL491821 | — | — | 1 | 5.76 |
| CHEMBL491618 | — | — | 1 | 5.67 |
| CHEMBL491001 | AMORPHISPIRONONE | — | 1 | 5.13 |
| CHEMBL445232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241806 | TEPHROSIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL301982 | CELASTROL | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL419669 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL393417 | DEGUELIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL500257 | AMORPHASTILBOL | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL491820 | AMORFRUTIN A | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL494083 | XANTHOANGELOL | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL490809 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL490810 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL491821 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL491618 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL491001 | AMORPHISPIRONONE | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL445232 | — | IC50 | > | 50000.0 | nM | - |