Assay Detail
Binding
CHEMBL1028243
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Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.53 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | — | 1 | 6.52 |
| CHEMBL500257 | AMORPHASTILBOL | — | 1 | 6.17 |
| CHEMBL393417 | DEGUELIN | — | 1 | 5.76 |
| CHEMBL494083 | XANTHOANGELOL | — | 1 | 5.74 |
| CHEMBL241806 | TEPHROSIN | — | 1 | 5.70 |
| CHEMBL490809 | — | — | 1 | 5.61 |
| CHEMBL491821 | — | — | 1 | 5.52 |
| CHEMBL490810 | — | — | 1 | 5.50 |
| CHEMBL491820 | AMORFRUTIN A | — | 1 | 5.38 |
| CHEMBL419669 | — | — | 1 | 5.38 |
| CHEMBL491618 | — | — | 1 | 5.12 |
| CHEMBL491001 | AMORPHISPIRONONE | — | 1 | 4.86 |
| CHEMBL445232 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL500257 | AMORPHASTILBOL | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL393417 | DEGUELIN | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL494083 | XANTHOANGELOL | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL241806 | TEPHROSIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL490809 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL491821 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL490810 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL491820 | AMORFRUTIN A | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL419669 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL491618 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL491001 | AMORPHISPIRONONE | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL445232 | — | IC50 | = | 24700.0 | nM | 4.61 |