Assay Detail
Binding
CHEMBL1028494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]alpha-bungarotoxin from alpha7 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.41 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | 3.0 | 1 | 6.48 |
| CHEMBL502295 | — | — | 1 | 6.36 |
| CHEMBL502030 | — | — | 1 | 6.26 |
| CHEMBL190851 | — | — | 1 | 5.91 |
| CHEMBL502029 | — | — | 1 | 5.65 |
| CHEMBL483804 | — | — | 1 | 5.44 |
| CHEMBL525735 | — | — | 1 | 5.38 |
| CHEMBL500426 | — | — | 1 | 4.89 |
| CHEMBL497946 | — | — | 1 | 4.60 |
| CHEMBL519673 | — | — | 1 | 4.40 |
| CHEMBL524813 | — | — | 1 | 4.10 |
| CHEMBL497940 | — | — | 1 | - |
| CHEMBL522410 | — | — | 1 | - |
| CHEMBL498277 | — | — | 1 | - |
| CHEMBL499635 | — | — | 1 | - |
| CHEMBL508190 | — | — | 1 | - |
| CHEMBL525734 | — | — | 1 | - |
| CHEMBL502374 | — | — | 1 | - |
| CHEMBL526340 | — | — | 1 | - |
| CHEMBL442613 | — | — | 1 | - |
| CHEMBL498810 | — | — | 1 | - |
| CHEMBL521152 | — | — | 1 | - |
| CHEMBL483803 | — | — | 1 | - |
| CHEMBL508431 | — | — | 1 | - |
| CHEMBL520478 | — | — | 1 | - |
| CHEMBL484148 | — | — | 1 | - |
| CHEMBL499636 | — | — | 1 | - |
| CHEMBL526554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | Ki | = | 331.0 | nM | 6.48 |
| CHEMBL502295 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL502030 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL190851 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL502029 | — | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL483804 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL525735 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL500426 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL497946 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL519673 | — | Ki | = | 39700.0 | nM | 4.40 |
| CHEMBL524813 | — | Ki | = | 78700.0 | nM | 4.10 |
| CHEMBL497940 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL522410 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL498277 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL499635 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL508190 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL525734 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL502374 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL526340 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL442613 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL498810 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL521152 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL483803 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL508431 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL520478 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL484148 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL499636 | — | Ki | - | — | - | |
| CHEMBL526554 | — | Ki | - | — | - |