Assay Detail
Binding
CHEMBL1028889
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Inhibition of human recombinant PARP1 by Trevigen colorimetric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.31 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471966 | — | — | 1 | 6.30 |
| CHEMBL526128 | — | — | 1 | 6.10 |
| CHEMBL480429 | — | — | 1 | 6.05 |
| CHEMBL481591 | — | — | 1 | 5.96 |
| CHEMBL446240 | — | — | 1 | 5.75 |
| CHEMBL502330 | — | — | 1 | 5.72 |
| CHEMBL504903 | — | — | 1 | 5.66 |
| CHEMBL501330 | — | — | 1 | 5.64 |
| CHEMBL504998 | — | — | 1 | 5.47 |
| CHEMBL453989 | — | — | 1 | 5.43 |
| CHEMBL481793 | — | — | 1 | 5.24 |
| CHEMBL450259 | — | — | 1 | 4.82 |
| CHEMBL481803 | — | — | 1 | 4.64 |
| CHEMBL480428 | — | — | 1 | 4.57 |
| CHEMBL480427 | — | — | 1 | 4.37 |
| CHEMBL479635 | — | — | 1 | 4.28 |
| CHEMBL480233 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471966 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL526128 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL480429 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL481591 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL446240 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL502330 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL504903 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL501330 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL504998 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL453989 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL481793 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL450259 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL481803 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL480428 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL480427 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL479635 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL480233 | — | IC50 | = | 62000.0 | nM | 4.21 |