Assay Detail
Binding
CHEMBL1028959
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.34 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522152 | — | — | 1 | 9.60 |
| CHEMBL200732 | — | — | 1 | 9.42 |
| CHEMBL119709 | IB-MECA | — | 1 | 9.00 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.85 |
| CHEMBL494086 | — | — | 1 | 8.82 |
| CHEMBL500569 | — | — | 1 | 8.60 |
| CHEMBL493888 | — | — | 1 | 8.32 |
| CHEMBL226585 | — | — | 1 | 8.21 |
| CHEMBL387921 | — | — | 1 | 8.21 |
| CHEMBL522856 | — | — | 1 | 8.17 |
| CHEMBL509055 | — | — | 1 | 8.14 |
| CHEMBL436485 | — | — | 1 | 7.81 |
| CHEMBL226581 | — | — | 1 | 7.44 |
| CHEMBL388145 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522152 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL200732 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL119709 | IB-MECA | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL494086 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL500569 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL493888 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL226585 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL387921 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL522856 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL509055 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL436485 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL226581 | — | Ki | = | 36.2 | nM | 7.44 |
| CHEMBL388145 | — | Ki | = | 658.0 | nM | 6.18 |