Assay Detail
Functional
CHEMBL1028973
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Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.89 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333964 | — | — | 1 | 5.55 |
| CHEMBL122005 | (S)-WILLARDIINE | — | 1 | 4.94 |
| CHEMBL337577 | — | — | 1 | 4.60 |
| CHEMBL121915 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333964 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL122005 | (S)-WILLARDIINE | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL337577 | — | EC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL121915 | — | EC50 | = | 33600.0 | nM | 4.47 |