Assay Detail
Binding
CHEMBL1029026
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Binding affinity to human integrin alpha2beta3 receptor by TRF assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.16 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471675 | — | — | 1 | 6.78 |
| CHEMBL474902 | — | — | 1 | 6.49 |
| CHEMBL464400 | — | — | 1 | 5.20 |
| CHEMBL464398 | — | — | 1 | - |
| CHEMBL464399 | — | — | 1 | - |
| CHEMBL518086 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471675 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL474902 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL464400 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL464398 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL464399 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL518086 | — | IC50 | > | 10000.0 | nM | - |