Assay Detail
Functional
CHEMBL1029029
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Inhibition of FGF-induced HUVEC proliferation after 48 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.67 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474902 | — | — | 1 | 5.96 |
| CHEMBL471675 | — | — | 1 | 5.54 |
| CHEMBL411941 | CYCLORGDFV | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474902 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL471675 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 3100.0 | nM | 5.51 |