Assay Detail
Binding
CHEMBL1029035
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Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.47 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515921 | — | — | 1 | 9.85 |
| CHEMBL474689 | — | — | 1 | 9.59 |
| CHEMBL474688 | — | — | 1 | 9.46 |
| CHEMBL473269 | — | — | 1 | 9.46 |
| CHEMBL225155 | — | — | 1 | 9.33 |
| CHEMBL475495 | — | — | 1 | 9.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515921 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL474689 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL474688 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL473269 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL225155 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL475495 | — | IC50 | = | 0.73 | nM | 9.14 |