Assay Detail
Functional
CHEMBL1029040
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Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS binding
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.83 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473269 | — | — | 1 | 9.35 |
| CHEMBL474689 | — | — | 1 | 9.26 |
| CHEMBL515921 | — | — | 1 | 8.96 |
| CHEMBL474688 | — | — | 1 | 8.68 |
| CHEMBL475495 | — | — | 1 | 8.62 |
| CHEMBL225155 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473269 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL474689 | — | EC50 | = | 0.55 | nM | 9.26 |
| CHEMBL515921 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL474688 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL475495 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL225155 | — | EC50 | = | 7.9 | nM | 8.10 |