Assay Detail
Binding
CHEMBL1029351
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Inhibition of Dictyostelium discoideum AX2 RNase P by double reciprocal plot
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dictyostelium discoideum AX2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.39 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71150 | — | — | 1 | 6.30 |
| CHEMBL538971 | — | — | 1 | 6.02 |
| CHEMBL556543 | — | — | 1 | 5.96 |
| CHEMBL551225 | — | — | 1 | 5.62 |
| CHEMBL541264 | N1-Acitretinylspermine | — | 1 | 5.61 |
| CHEMBL1131 | ACITRETIN | 4.0 | 1 | 5.10 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 4.82 |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 1 | 4.70 |
| CHEMBL275311 | — | — | 1 | 4.35 |
| CHEMBL986 | RETINOL | 4.0 | 1 | - |
| CHEMBL554474 | TEMAROTENE | 2.0 | 1 | - |
| CHEMBL549872 | ETAROTENE | 2.0 | 1 | - |
| CHEMBL22369 | AROTINOID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71150 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL538971 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL556543 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL551225 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL541264 | N1-Acitretinylspermine | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL1131 | ACITRETIN | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL38 | TRETINOIN | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL547 | ISOTRETINOIN | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL275311 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL986 | RETINOL | Ki | = | 1475000.0 | nM | - |
| CHEMBL554474 | TEMAROTENE | Ki | = | 2800000.0 | nM | - |
| CHEMBL549872 | ETAROTENE | Ki | = | 3600000.0 | nM | - |
| CHEMBL22369 | AROTINOID | Ki | = | 4350000.0 | nM | - |