Assay Detail
Functional
CHEMBL1029759
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Cytotoxicity against human PC3 cells after 72 hrs by WST1 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.27 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444562 | — | — | 1 | 5.80 |
| CHEMBL482340 | — | — | 1 | 5.79 |
| CHEMBL474256 | — | — | 1 | 5.35 |
| CHEMBL444693 | — | — | 1 | 5.22 |
| CHEMBL499940 | — | — | 1 | 4.80 |
| CHEMBL502039 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444562 | — | IC50 | = | 1576.0 | nM | 5.80 |
| CHEMBL482340 | — | IC50 | = | 1609.0 | nM | 5.79 |
| CHEMBL474256 | — | IC50 | = | 4469.0 | nM | 5.35 |
| CHEMBL444693 | — | IC50 | = | 5977.0 | nM | 5.22 |
| CHEMBL499940 | — | IC50 | = | 15980.0 | nM | 4.80 |
| CHEMBL502039 | — | IC50 | = | 23331.0 | nM | 4.63 |