Assay Detail
Binding
CHEMBL1030561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MRCK after 75 mins by kinase-glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.75 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485215 | — | — | 1 | 6.43 |
| CHEMBL485214 | — | — | 1 | 5.92 |
| CHEMBL521179 | SR-3677 | — | 1 | 5.92 |
| CHEMBL510515 | — | — | 1 | 5.31 |
| CHEMBL485213 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485215 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL485214 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL521179 | SR-3677 | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL510515 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL485213 | — | IC50 | = | 7050.0 | nM | 5.15 |