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Assay Detail

CHEMBL1030615

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55940 from human cloned CB1 receptor by scintillation spectrometry
ChEMBL ↗
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 1 (CHEMBL218) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

CB2 selective sulfamoyl benzamides: optimization of the amide functionality.
Goodman AJ, Ajello CW, Worm K, Le Bourdonnec B, Savolainen MA, O'Hare H, Cassel JA, Stabley GJ, Dehaven RN, Labuda CJ, Koblish M, Little PJ, Brogdon BL, Smith SA, Dolle RE.
Bioorg Med Chem Lett (2009) 19 : 309 -313
PubMed 19091565 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 34 6.18 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL516388 — — 1 6.89
CHEMBL515102 — — 1 6.89
CHEMBL473697 — — 1 6.85
CHEMBL474897 — — 1 6.70
CHEMBL475093 — — 1 6.58
CHEMBL472679 — — 1 6.57
CHEMBL470233 — — 1 6.57
CHEMBL503518 — — 1 6.51
CHEMBL258242 — — 1 6.51
CHEMBL474896 — — 1 6.41
CHEMBL511150 — — 1 6.33
CHEMBL508362 — — 1 6.29
CHEMBL473698 — — 1 6.28
CHEMBL473063 — — 1 6.27
CHEMBL475100 — — 1 6.25
CHEMBL515090 — — 1 6.19
CHEMBL472680 — — 1 6.13
CHEMBL474080 — — 1 6.12
CHEMBL475719 — — 1 6.11
CHEMBL474692 — — 1 6.10
CHEMBL516368 — — 1 5.96
CHEMBL500856 — — 1 5.96
CHEMBL474300 — — 1 5.96
CHEMBL516057 — — 1 5.92
CHEMBL471671 — — 1 5.92
CHEMBL515866 — — 1 5.92
CHEMBL514324 — — 1 5.85
CHEMBL514490 — — 1 5.75
CHEMBL470231 — — 1 5.72
CHEMBL525791 — — 1 5.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL516388 — Ki = 130.0 nM 6.89
CHEMBL515102 — Ki = 130.0 nM 6.89
CHEMBL473697 — Ki = 140.0 nM 6.85
CHEMBL474897 — Ki = 200.0 nM 6.70
CHEMBL475093 — Ki = 260.0 nM 6.58
CHEMBL472679 — Ki = 270.0 nM 6.57
CHEMBL470233 — Ki = 270.0 nM 6.57
CHEMBL503518 — Ki = 310.0 nM 6.51
CHEMBL258242 — Ki = 310.0 nM 6.51
CHEMBL474896 — Ki = 390.0 nM 6.41
CHEMBL511150 — Ki = 470.0 nM 6.33
CHEMBL508362 — Ki = 510.0 nM 6.29
CHEMBL473698 — Ki = 530.0 nM 6.28
CHEMBL473063 — Ki = 540.0 nM 6.27
CHEMBL475100 — Ki = 560.0 nM 6.25
CHEMBL515090 — Ki = 640.0 nM 6.19
CHEMBL472680 — Ki = 740.0 nM 6.13
CHEMBL474080 — Ki = 750.0 nM 6.12
CHEMBL475719 — Ki = 770.0 nM 6.11
CHEMBL474692 — Ki = 790.0 nM 6.10
CHEMBL516368 — Ki = 1100.0 nM 5.96
CHEMBL500856 — Ki = 1100.0 nM 5.96
CHEMBL474300 — Ki = 1100.0 nM 5.96
CHEMBL516057 — Ki = 1200.0 nM 5.92
CHEMBL471671 — Ki = 1200.0 nM 5.92
CHEMBL515866 — Ki = 1200.0 nM 5.92
CHEMBL514324 — Ki = 1400.0 nM 5.85
CHEMBL514490 — Ki = 1800.0 nM 5.75
CHEMBL470231 — Ki = 1900.0 nM 5.72
CHEMBL525791 — Ki = 2900.0 nM 5.54
CHEMBL472856 — Ki = 3400.0 nM 5.47
CHEMBL474506 — Ki = 6990.0 nM 5.16
CHEMBL473696 — Ki > 5000.0 nM -
CHEMBL475493 — Ki > 1000.0 nM -