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Assay Detail

CHEMBL1030622

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]nociceptin from human NOP expressed in CHO cells
ChEMBL ↗
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Nociceptin receptor (CHEMBL2014) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
Caldwell JP, Matasi JJ, Fernandez X, McLeod RL, Zhang H, Fawzi A, Tulshian DB.
Bioorg Med Chem Lett (2009) 19 : 1164 -1167
PubMed 19147350 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 68 8.34 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL473700 — — 1 9.40
CHEMBL515575 — — 1 9.40
CHEMBL474096 — — 1 9.30
CHEMBL472669 — — 1 9.30
CHEMBL516389 — — 1 9.30
CHEMBL473279 — — 1 9.30
CHEMBL475310 — — 1 9.30
CHEMBL471880 — — 1 9.22
CHEMBL514662 — — 1 9.22
CHEMBL515142 — — 1 9.15
CHEMBL475707 — — 1 9.15
CHEMBL471882 — — 1 9.15
CHEMBL517167 — — 1 9.10
CHEMBL473278 — — 1 9.10
CHEMBL514463 — — 1 9.05
CHEMBL515091 — — 1 9.05
CHEMBL475094 — — 1 9.05
CHEMBL473272 — — 1 9.00
CHEMBL473701 — — 1 9.00
CHEMBL239822 — — 1 8.89
CHEMBL514489 — — 1 8.85
CHEMBL473898 — — 1 8.85
CHEMBL474092 — — 1 8.82
CHEMBL474687 — — 1 8.80
CHEMBL474283 — — 1 8.77
CHEMBL511161 — — 1 8.74
CHEMBL474485 — — 1 8.68
CHEMBL475096 — — 1 8.68
CHEMBL515829 — — 1 8.67
CHEMBL457451 — — 1 8.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL473700 — Ki = 0.4 nM 9.40
CHEMBL515575 — Ki = 0.4 nM 9.40
CHEMBL472669 — Ki = 0.5 nM 9.30
CHEMBL516389 — Ki = 0.5 nM 9.30
CHEMBL473279 — Ki = 0.5 nM 9.30
CHEMBL475310 — Ki = 0.5 nM 9.30
CHEMBL474096 — Ki = 0.5 nM 9.30
CHEMBL471880 — Ki = 0.6 nM 9.22
CHEMBL514662 — Ki = 0.6 nM 9.22
CHEMBL515142 — Ki = 0.7 nM 9.15
CHEMBL475707 — Ki = 0.7 nM 9.15
CHEMBL471882 — Ki = 0.7 nM 9.15
CHEMBL517167 — Ki = 0.8 nM 9.10
CHEMBL473278 — Ki = 0.8 nM 9.10
CHEMBL475094 — Ki = 0.9 nM 9.05
CHEMBL515091 — Ki = 0.9 nM 9.05
CHEMBL514463 — Ki = 0.9 nM 9.05
CHEMBL473272 — Ki = 1.0 nM 9.00
CHEMBL473701 — Ki = 1.0 nM 9.00
CHEMBL239822 — Ki = 1.3 nM 8.89
CHEMBL514489 — Ki = 1.4 nM 8.85
CHEMBL473898 — Ki = 1.4 nM 8.85
CHEMBL474092 — Ki = 1.5 nM 8.82
CHEMBL474687 — Ki = 1.6 nM 8.80
CHEMBL474283 — Ki = 1.7 nM 8.77
CHEMBL511161 — Ki = 1.8 nM 8.74
CHEMBL475096 — Ki = 2.1 nM 8.68
CHEMBL474485 — Ki = 2.1 nM 8.68
CHEMBL515829 — Ki = 2.15 nM 8.67
CHEMBL457451 — Ki = 2.25 nM 8.65
CHEMBL473904 — Ki = 2.3 nM 8.64
CHEMBL240215 — Ki = 2.3 nM 8.64
CHEMBL518325 — Ki = 2.55 nM 8.59
CHEMBL457244 — Ki = 2.75 nM 8.56
CHEMBL464191 — Ki = 3.2 nM 8.49
CHEMBL460636 — Ki = 3.5 nM 8.46
CHEMBL511162 — Ki = 3.6 nM 8.44
CHEMBL517265 — Ki = 3.7 nM 8.43
CHEMBL501088 — Ki = 3.8 nM 8.42
CHEMBL473068 — Ki = 4.05 nM 8.39
CHEMBL511649 — Ki = 4.5 nM 8.35
CHEMBL510745 — Ki = 5.0 nM 8.30
CHEMBL471262 — Ki = 5.4 nM 8.27
CHEMBL241272 — Ki = 6.8 nM 8.17
CHEMBL473280 — Ki = 6.7 nM 8.17
CHEMBL464192 — Ki = 8.0 nM 8.10
CHEMBL456225 — Ki = 8.65 nM 8.06
CHEMBL499169 — Ki = 12.1 nM 7.92
CHEMBL472086 — Ki = 12.2 nM 7.91
CHEMBL516187 — Ki = 15.9 nM 7.80