Assay Detail
Binding
CHEMBL1030623
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Displacement of [125I]diprenorphine from human DOP expressed in CHO cells
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 67 | 5.63 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472867 | — | — | 1 | 7.50 |
| CHEMBL516389 | — | — | 1 | 6.43 |
| CHEMBL473701 | — | — | 1 | 6.42 |
| CHEMBL475310 | — | — | 1 | 6.42 |
| CHEMBL472669 | — | — | 1 | 6.35 |
| CHEMBL514662 | — | — | 1 | 6.29 |
| CHEMBL473904 | — | — | 1 | 6.27 |
| CHEMBL473068 | — | — | 1 | 6.24 |
| CHEMBL510745 | — | — | 1 | 6.12 |
| CHEMBL511649 | — | — | 1 | 6.10 |
| CHEMBL475096 | — | — | 1 | 6.06 |
| CHEMBL473700 | — | — | 1 | 6.06 |
| CHEMBL457244 | — | — | 1 | 6.06 |
| CHEMBL471880 | — | — | 1 | 6.05 |
| CHEMBL457451 | — | — | 1 | 6.04 |
| CHEMBL460636 | — | — | 1 | 6.03 |
| CHEMBL518325 | — | — | 1 | 6.02 |
| CHEMBL515829 | — | — | 1 | 5.99 |
| CHEMBL475707 | — | — | 1 | 5.97 |
| CHEMBL516187 | — | — | 1 | 5.97 |
| CHEMBL517265 | — | — | 1 | 5.95 |
| CHEMBL473898 | — | — | 1 | 5.91 |
| CHEMBL474485 | — | — | 1 | 5.89 |
| CHEMBL511162 | — | — | 1 | 5.89 |
| CHEMBL511161 | — | — | 1 | 5.88 |
| CHEMBL456225 | — | — | 1 | 5.82 |
| CHEMBL501088 | — | — | 1 | 5.81 |
| CHEMBL515091 | — | — | 1 | 5.79 |
| CHEMBL240215 | — | — | 1 | 5.79 |
| CHEMBL515142 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472867 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL516389 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL475310 | — | Ki | = | 376.0 | nM | 6.42 |
| CHEMBL473701 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL472669 | — | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL514662 | — | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL473904 | — | Ki | = | 538.0 | nM | 6.27 |
| CHEMBL473068 | — | Ki | = | 578.0 | nM | 6.24 |
| CHEMBL510745 | — | Ki | = | 759.0 | nM | 6.12 |
| CHEMBL511649 | — | Ki | = | 795.0 | nM | 6.10 |
| CHEMBL475096 | — | Ki | = | 868.0 | nM | 6.06 |
| CHEMBL473700 | — | Ki | = | 867.0 | nM | 6.06 |
| CHEMBL457244 | — | Ki | = | 878.0 | nM | 6.06 |
| CHEMBL471880 | — | Ki | = | 883.0 | nM | 6.05 |
| CHEMBL457451 | — | Ki | = | 906.0 | nM | 6.04 |
| CHEMBL460636 | — | Ki | = | 933.0 | nM | 6.03 |
| CHEMBL518325 | — | Ki | = | 955.0 | nM | 6.02 |
| CHEMBL515829 | — | Ki | = | 1033.0 | nM | 5.99 |
| CHEMBL475707 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL516187 | — | Ki | = | 1062.0 | nM | 5.97 |
| CHEMBL517265 | — | Ki | = | 1136.0 | nM | 5.95 |
| CHEMBL473898 | — | Ki | = | 1224.0 | nM | 5.91 |
| CHEMBL474485 | — | Ki | = | 1298.0 | nM | 5.89 |
| CHEMBL511162 | — | Ki | = | 1279.0 | nM | 5.89 |
| CHEMBL511161 | — | Ki | = | 1316.0 | nM | 5.88 |
| CHEMBL456225 | — | Ki | = | 1525.0 | nM | 5.82 |
| CHEMBL501088 | — | Ki | = | 1535.0 | nM | 5.81 |
| CHEMBL515091 | — | Ki | = | 1615.0 | nM | 5.79 |
| CHEMBL240215 | — | Ki | = | 1633.0 | nM | 5.79 |
| CHEMBL515142 | — | Ki | = | 1676.0 | nM | 5.78 |
| CHEMBL471882 | — | Ki | = | 1693.0 | nM | 5.77 |
| CHEMBL239822 | — | Ki | = | 1790.0 | nM | 5.75 |
| CHEMBL473279 | — | Ki | = | 1802.0 | nM | 5.74 |
| CHEMBL514463 | — | Ki | = | 1951.0 | nM | 5.71 |
| CHEMBL474687 | — | Ki | = | 2064.0 | nM | 5.68 |
| CHEMBL474092 | — | Ki | = | 2096.0 | nM | 5.68 |
| CHEMBL517167 | — | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL473272 | — | Ki | = | 2340.0 | nM | 5.63 |
| CHEMBL464191 | — | Ki | = | 2381.0 | nM | 5.62 |
| CHEMBL475094 | — | Ki | = | 2515.0 | nM | 5.60 |
| CHEMBL515575 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL474283 | — | Ki | = | 2639.0 | nM | 5.58 |
| CHEMBL473278 | — | Ki | = | 2879.0 | nM | 5.54 |
| CHEMBL473280 | — | Ki | = | 2980.0 | nM | 5.53 |
| CHEMBL471262 | — | Ki | = | 3103.0 | nM | 5.51 |
| CHEMBL464192 | — | Ki | = | 3176.0 | nM | 5.50 |
| CHEMBL474096 | — | Ki | = | 3948.0 | nM | 5.40 |
| CHEMBL499169 | — | Ki | = | 4758.0 | nM | 5.32 |
| CHEMBL472086 | — | Ki | = | 5022.0 | nM | 5.30 |
| CHEMBL514489 | — | Ki | = | 5016.0 | nM | 5.30 |