Assay Detail
Binding
CHEMBL1030624
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Displacement of [125I]diprenorphine from human KOP expressed in CHO cells
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 67 | 6.70 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475310 | — | — | 1 | 8.10 |
| CHEMBL473700 | — | — | 1 | 8.00 |
| CHEMBL516187 | — | — | 1 | 7.96 |
| CHEMBL514662 | — | — | 1 | 7.89 |
| CHEMBL511161 | — | — | 1 | 7.85 |
| CHEMBL473904 | — | — | 1 | 7.82 |
| CHEMBL471880 | — | — | 1 | 7.60 |
| CHEMBL472669 | — | — | 1 | 7.60 |
| CHEMBL471882 | — | — | 1 | 7.58 |
| CHEMBL516389 | — | — | 1 | 7.54 |
| CHEMBL514463 | — | — | 1 | 7.48 |
| CHEMBL474687 | — | — | 1 | 7.41 |
| CHEMBL475707 | — | — | 1 | 7.40 |
| CHEMBL473272 | — | — | 1 | 7.35 |
| CHEMBL474092 | — | — | 1 | 7.35 |
| CHEMBL474485 | — | — | 1 | 7.32 |
| CHEMBL515091 | — | — | 1 | 7.31 |
| CHEMBL240215 | — | — | 1 | 7.28 |
| CHEMBL515142 | — | — | 1 | 7.27 |
| CHEMBL511649 | — | — | 1 | 7.25 |
| CHEMBL473701 | — | — | 1 | 7.25 |
| CHEMBL473279 | — | — | 1 | 7.19 |
| CHEMBL464191 | — | — | 1 | 7.19 |
| CHEMBL514489 | — | — | 1 | 7.17 |
| CHEMBL517167 | — | — | 1 | 7.17 |
| CHEMBL515575 | — | — | 1 | 7.09 |
| CHEMBL473280 | — | — | 1 | 7.07 |
| CHEMBL474096 | — | — | 1 | 6.86 |
| CHEMBL240657 | — | — | 1 | 6.86 |
| CHEMBL510201 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475310 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL473700 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL516187 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL514662 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL511161 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL473904 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL471880 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL472669 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL471882 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL516389 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL514463 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL474687 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL475707 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL474092 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL473272 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL474485 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL515091 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL240215 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL515142 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL511649 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL473701 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL473279 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL464191 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL514489 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL517167 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL515575 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL473280 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL474096 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL240657 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL510201 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL511162 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL472086 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL515829 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL473898 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL473278 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL475094 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL510745 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL457244 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL456225 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL457451 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL501088 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL464192 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL460636 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL518325 | — | Ki | = | 469.0 | nM | 6.33 |
| CHEMBL475096 | — | Ki | = | 497.0 | nM | 6.30 |
| CHEMBL474091 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL239822 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL472676 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL472677 | — | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL474283 | — | Ki | = | 655.0 | nM | 6.18 |