Assay Detail
Binding
CHEMBL1030765
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Inhibition of NF-kappaB-mediated transcriptional activity transfected in PMA-stimulated HEK293 cells after 24 hrs by luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.28 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522660 | — | — | 1 | 5.69 |
| CHEMBL449718 | — | — | 1 | 5.55 |
| CHEMBL522347 | — | — | 1 | 5.22 |
| CHEMBL477923 | — | — | 1 | 5.13 |
| CHEMBL507441 | — | — | 1 | 5.06 |
| CHEMBL4298697 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522660 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL449718 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL522347 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL477923 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL507441 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4298697 | — | IC50 | = | 9760.0 | nM | 5.01 |