Assay Detail
Binding
CHEMBL1030770
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Inhibition of DPP4
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.80 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493543 | — | — | 1 | 8.70 |
| CHEMBL2364733 | — | — | 1 | 8.70 |
| CHEMBL492733 | — | — | 1 | 8.30 |
| CHEMBL494146 | — | — | 1 | 8.30 |
| CHEMBL474048 | — | — | 1 | 8.22 |
| CHEMBL494340 | — | — | 1 | 8.22 |
| CHEMBL475465 | — | — | 1 | 8.15 |
| CHEMBL474049 | — | — | 1 | 8.15 |
| CHEMBL492536 | — | — | 1 | 8.15 |
| CHEMBL474808 | — | — | 1 | 8.10 |
| CHEMBL475662 | — | — | 1 | 8.10 |
| CHEMBL474047 | — | — | 1 | 8.05 |
| CHEMBL474211 | — | — | 1 | 8.00 |
| CHEMBL493544 | — | — | 1 | 8.00 |
| CHEMBL474983 | — | — | 1 | 7.96 |
| CHEMBL475863 | — | — | 1 | 7.92 |
| CHEMBL474003 | — | — | 1 | 7.92 |
| CHEMBL514317 | — | — | 1 | 7.89 |
| CHEMBL475870 | — | — | 1 | 7.85 |
| CHEMBL474800 | — | — | 1 | 7.82 |
| CHEMBL474025 | — | — | 1 | 7.80 |
| CHEMBL475634 | — | — | 1 | 7.77 |
| CHEMBL474982 | — | — | 1 | 7.72 |
| CHEMBL474394 | — | — | 1 | 7.66 |
| CHEMBL514006 | — | — | 1 | 7.60 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.52 |
| CHEMBL516080 | — | — | 1 | 7.51 |
| CHEMBL475169 | — | — | 1 | 7.51 |
| CHEMBL474002 | — | — | 1 | 7.51 |
| CHEMBL494147 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493543 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2364733 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL492733 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL494146 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL474048 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL494340 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL475465 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL474049 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL492536 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL474808 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL475662 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL474047 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL474211 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL493544 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL474983 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL475863 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL474003 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL514317 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL475870 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL474800 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL474025 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL475634 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL474982 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL474394 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL514006 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL516080 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL474002 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL475169 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL494147 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL515435 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL494339 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL522002 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL493760 | — | IC50 | = | 1600.0 | nM | 5.80 |