Assay Detail
Binding
CHEMBL1031093
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Displacement of [3H]spiperone from human cloned dopamine D2L receptor V2.61F/FV3.28,3.29LM mutant expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.01 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561763 | — | — | 1 | 7.46 |
| CHEMBL562620 | — | — | 1 | 7.27 |
| CHEMBL550222 | — | — | 1 | 7.19 |
| CHEMBL310843 | — | — | 1 | 7.18 |
| CHEMBL140612 | — | — | 1 | 6.96 |
| CHEMBL142020 | — | — | 1 | 6.66 |
| CHEMBL561622 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561763 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL562620 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL550222 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL310843 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL140612 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL142020 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL561622 | — | Ki | = | 470.0 | nM | 6.33 |