Assay Detail
Binding
CHEMBL1031095
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Displacement of [3H]spiperone from human cloned dopamine D2L receptor H6.55A mutant expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.86 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561763 | — | — | 1 | 7.58 |
| CHEMBL562620 | — | — | 1 | 7.20 |
| CHEMBL140612 | — | — | 1 | 7.09 |
| CHEMBL550222 | — | — | 1 | 6.89 |
| CHEMBL561622 | — | — | 1 | 6.77 |
| CHEMBL310843 | — | — | 1 | 6.50 |
| CHEMBL142020 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561763 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL562620 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL140612 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL550222 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL561622 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL310843 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL142020 | — | Ki | = | 1000.0 | nM | 6.00 |