Assay Detail
Binding
CHEMBL1031100
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Displacement of [3H]spiperone from human cloned dopamine D3 receptor L2.64F mutant expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.27 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550222 | — | — | 1 | 7.24 |
| CHEMBL142020 | — | — | 1 | 6.30 |
| CHEMBL562620 | — | — | 1 | 6.14 |
| CHEMBL561763 | — | — | 1 | 6.13 |
| CHEMBL140612 | — | — | 1 | 5.99 |
| CHEMBL310843 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550222 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL142020 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL562620 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL561763 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL140612 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL310843 | — | Ki | = | 1600.0 | nM | 5.80 |