Assay Detail
Binding
CHEMBL1031101
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Displacement of [3H]spiperone from human cloned dopamine D3 receptor FV3.28,3.29LM mutant expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.62 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550222 | — | — | 1 | 7.48 |
| CHEMBL562620 | — | — | 1 | 7.36 |
| CHEMBL142020 | — | — | 1 | 6.54 |
| CHEMBL561763 | — | — | 1 | 6.37 |
| CHEMBL561622 | — | — | 1 | 6.28 |
| CHEMBL140612 | — | — | 1 | 6.20 |
| CHEMBL310843 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550222 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL562620 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL142020 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL561763 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL561622 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL140612 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL310843 | — | Ki | = | 730.0 | nM | 6.14 |