Assay Detail
Binding
CHEMBL1031102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human cloned dopamine D3 receptor V2.61F/FV3.28,3.29LM mutant expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.83 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550222 | — | — | 1 | 7.75 |
| CHEMBL562620 | — | — | 1 | 7.29 |
| CHEMBL310843 | — | — | 1 | 7.12 |
| CHEMBL142020 | — | — | 1 | 7.01 |
| CHEMBL561763 | — | — | 1 | 6.50 |
| CHEMBL140612 | — | — | 1 | 6.19 |
| CHEMBL561622 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550222 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL562620 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL310843 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL142020 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL561763 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL140612 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL561622 | — | Ki | = | 1100.0 | nM | 5.96 |