Assay Detail
Binding
CHEMBL1031298
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Inhibition of GSK3-beta
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of the potent aurora inhibitor MK-0457 (VX-680).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.91 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551633 | — | — | 1 | 8.10 |
| CHEMBL549668 | — | — | 1 | 7.77 |
| CHEMBL359482 | — | — | 1 | 7.66 |
| CHEMBL552038 | — | — | 1 | 7.62 |
| CHEMBL562416 | — | — | 1 | 7.48 |
| CHEMBL562157 | — | — | 1 | 7.36 |
| CHEMBL564459 | — | — | 1 | 7.32 |
| CHEMBL565205 | — | — | 1 | 7.29 |
| CHEMBL552033 | — | — | 1 | 7.17 |
| CHEMBL549536 | — | — | 1 | 7.14 |
| CHEMBL561834 | — | — | 1 | 6.95 |
| CHEMBL552500 | — | — | 1 | 6.91 |
| CHEMBL562415 | — | — | 1 | 6.90 |
| CHEMBL549322 | — | — | 1 | 6.77 |
| CHEMBL551634 | — | — | 1 | 6.67 |
| CHEMBL550825 | — | — | 1 | 6.51 |
| CHEMBL561421 | — | — | 1 | 6.47 |
| CHEMBL560158 | — | — | 1 | 6.22 |
| CHEMBL484950 | — | — | 1 | 5.99 |
| CHEMBL564290 | — | — | 1 | 5.93 |
| CHEMBL564449 | — | — | 1 | 5.88 |
| CHEMBL564941 | — | — | 1 | 5.82 |
| CHEMBL559900 | — | — | 1 | - |
| CHEMBL556460 | — | — | 1 | - |
| CHEMBL552385 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551633 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL549668 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL359482 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL552038 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL562416 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL562157 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL564459 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL565205 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL552033 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL549536 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL561834 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL552500 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL562415 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL549322 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL551634 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL550825 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL561421 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL560158 | — | Ki | = | 605.0 | nM | 6.22 |
| CHEMBL484950 | — | Ki | = | 1034.0 | nM | 5.99 |
| CHEMBL564290 | — | Ki | = | 1168.0 | nM | 5.93 |
| CHEMBL564449 | — | Ki | = | 1314.0 | nM | 5.88 |
| CHEMBL564941 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL559900 | — | Ki | > | 150.0 | nM | - |
| CHEMBL556460 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL552385 | — | Ki | > | 15.0 | nM | - |