Assay Detail
Binding
CHEMBL1031376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.63 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485214 | — | — | 1 | 8.82 |
| CHEMBL521179 | SR-3677 | — | 1 | 8.49 |
| CHEMBL485215 | — | — | 1 | 8.48 |
| CHEMBL510515 | — | — | 1 | 8.14 |
| CHEMBL485213 | — | — | 1 | 7.34 |
| CHEMBL485568 | — | — | 1 | 6.12 |
| CHEMBL485567 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485214 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL521179 | SR-3677 | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL485215 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL510515 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL485213 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL485568 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL485567 | — | IC50 | = | 920.0 | nM | 6.04 |