Assay Detail
Binding
CHEMBL1031479
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Displacement of [125I]echistatin from integrin alphaVbeta3 receptor in human placenta by microplate scintillation counter
6
Total Activities
4
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.57 | 8.25 |
| IC50H | 1 | - | - |
| IC50L | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460012 | — | — | 1 | 8.25 |
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 7.72 |
| CHEMBL443362 | — | — | 3 | 7.49 |
| CHEMBL452724 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460012 | — | IC50 | = | 5.64 | nM | 8.25 |
| CHEMBL429876 | CILENGITIDE | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL443362 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL452724 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL443362 | — | IC50H | = | 6.5 | nM | - |
| CHEMBL443362 | — | IC50L | = | 458.0 | nM | - |