Assay Detail
Functional
CHEMBL1031507
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Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.79 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509430 | — | — | 1 | 5.72 |
| CHEMBL500370 | — | — | 1 | 5.58 |
| CHEMBL23236 | BETULIN | — | 1 | 5.42 |
| CHEMBL509927 | — | — | 1 | 5.14 |
| CHEMBL237068 | — | — | 1 | 5.14 |
| CHEMBL503608 | — | — | 1 | 5.00 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.99 |
| CHEMBL397553 | — | — | 1 | 4.92 |
| CHEMBL444941 | HEDERACOLCHISIDE A1 | — | 1 | 4.82 |
| CHEMBL502407 | — | — | 1 | 4.82 |
| CHEMBL396650 | — | — | 1 | 4.82 |
| CHEMBL444506 | — | — | 1 | 4.78 |
| CHEMBL509798 | — | — | 1 | 4.64 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.57 |
| CHEMBL447565 | ALPHA-HEDERIN | — | 1 | 4.48 |
| CHEMBL237890 | — | — | 1 | 4.47 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | 4.41 |
| CHEMBL452911 | — | — | 1 | 4.24 |
| CHEMBL455747 | Hederagenin-3-O-beta-D-glucopyranoside | — | 1 | 4.23 |
| CHEMBL479310 | HEDERACOLCHISIDE A | — | 1 | 4.23 |
| CHEMBL503523 | — | — | 1 | 4.12 |
| CHEMBL502465 | — | — | 1 | - |
| CHEMBL499529 | — | — | 1 | - |
| CHEMBL500006 | — | — | 1 | - |
| CHEMBL500097 | — | — | 1 | - |
| CHEMBL503115 | — | — | 1 | - |
| CHEMBL499456 | — | — | 1 | - |
| CHEMBL396944 | — | — | 1 | - |
| CHEMBL502316 | — | — | 1 | - |
| CHEMBL237708 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509430 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL500370 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL23236 | BETULIN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL509927 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL237068 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL503608 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL397553 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL444941 | HEDERACOLCHISIDE A1 | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL502407 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL396650 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL444506 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL509798 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL447565 | ALPHA-HEDERIN | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL237890 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL486400 | HEDERAGENIN | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL452911 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL479310 | HEDERACOLCHISIDE A | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL455747 | Hederagenin-3-O-beta-D-glucopyranoside | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL503523 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL501076 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL453268 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL507049 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL396425 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL396877 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237708 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL502316 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL396944 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL499456 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL503115 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL500097 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL500006 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL499529 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL502465 | — | IC50 | > | 100000.0 | nM | - |