Assay Detail
Functional
CHEMBL1031627
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum J164
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.40 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630 | — | — | 1 | 7.73 |
| CHEMBL453384 | — | — | 1 | 7.53 |
| CHEMBL502137 | — | — | 1 | 7.46 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL453384 | — | IC50 | = | 29.24 | nM | 7.53 |
| CHEMBL502137 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 133.5 | nM | 6.88 |