Assay Detail
Functional
CHEMBL1031831
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Cytotoxicity against human K562 cells after 72 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.25 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.44 |
| CHEMBL498271 | — | — | 1 | 8.30 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.54 |
| CHEMBL498107 | — | — | 1 | 7.42 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 7.39 |
| CHEMBL498108 | — | — | 1 | 7.28 |
| CHEMBL498106 | — | — | 1 | 6.12 |
| CHEMBL498447 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL498271 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL107 | COLCHICINE | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL498107 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL498108 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL498106 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL498447 | — | IC50 | = | 3100.0 | nM | 5.51 |