Assay Detail
Binding
CHEMBL1031834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization assessed as blockade of microtubule assembly
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.61 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.00 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 5.70 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.68 |
| CHEMBL498106 | — | — | 1 | 5.68 |
| CHEMBL498271 | — | — | 1 | 5.66 |
| CHEMBL508617 | — | — | 1 | 5.60 |
| CHEMBL498107 | — | — | 1 | 5.47 |
| CHEMBL452175 | — | — | 1 | 5.37 |
| CHEMBL498108 | — | — | 1 | 5.30 |
| CHEMBL498447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL107 | COLCHICINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL498106 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL498271 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL508617 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL498107 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL452175 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL498108 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL498447 | — | IC50 | - | — | - |