Assay Detail
Functional
CHEMBL1031848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human RS11846 cells after 1 to 2 days by FITC-annexin V and propidium iodide assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.24 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541496 | — | — | 1 | 5.52 |
| CHEMBL554545 | — | — | 1 | 5.52 |
| CHEMBL552287 | — | — | 1 | 5.51 |
| CHEMBL541005 | — | — | 1 | 5.50 |
| CHEMBL541427 | — | — | 1 | 5.39 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 5.38 |
| CHEMBL557761 | — | — | 1 | 5.38 |
| CHEMBL561820 | — | — | 1 | 5.35 |
| CHEMBL553474 | — | — | 1 | 5.34 |
| CHEMBL554132 | — | — | 1 | 5.33 |
| CHEMBL539480 | — | — | 1 | 5.32 |
| CHEMBL550422 | — | — | 1 | 5.32 |
| CHEMBL541004 | — | — | 1 | 5.31 |
| CHEMBL551288 | APOGOSSYPOL | — | 1 | 5.30 |
| CHEMBL554546 | — | — | 1 | 5.29 |
| CHEMBL539481 | — | — | 1 | 5.26 |
| CHEMBL554601 | — | — | 1 | 5.25 |
| CHEMBL538616 | — | — | 1 | 5.24 |
| CHEMBL554133 | — | — | 1 | 5.14 |
| CHEMBL564558 | — | — | 1 | 5.08 |
| CHEMBL541003 | — | — | 1 | 5.03 |
| CHEMBL552735 | — | — | 1 | 5.01 |
| CHEMBL540424 | — | — | 1 | 4.97 |
| CHEMBL556334 | — | — | 1 | 4.90 |
| CHEMBL554104 | — | — | 1 | 4.86 |
| CHEMBL555284 | — | — | 1 | 4.82 |
| CHEMBL540425 | — | — | 1 | - |
| CHEMBL561351 | — | — | 1 | - |
| CHEMBL560035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541496 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL554545 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL552287 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL541005 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL541427 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL51483 | GOSSYPOL | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL557761 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL561820 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL553474 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL554132 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL539480 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL550422 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL541004 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL551288 | APOGOSSYPOL | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL554546 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL539481 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL554601 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL538616 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL554133 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL564558 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL541003 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL552735 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL540424 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL556334 | — | EC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL554104 | — | EC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL555284 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL540425 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL561351 | — | EC50 | > | 24500.0 | nM | - |
| CHEMBL560035 | — | EC50 | > | 30000.0 | nM | - |