Assay Detail
Functional
CHEMBL1031920
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.33 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.80 |
| CHEMBL551845 | — | — | 1 | 5.22 |
| CHEMBL564560 | — | — | 1 | 4.70 |
| CHEMBL203360 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL551845 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL564560 | — | IC50 | = | 19820.0 | nM | 4.70 |
| CHEMBL203360 | — | IC50 | = | 26450.0 | nM | 4.58 |