Assay Detail
Binding
CHEMBL1031973
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Inhibition of histidine-tagged Bacillus anthracis Sterne recombinant DHFR expressed in Escherichia coli BL21 Star (DE3)pLysS up to 3 mins
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.84 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565020 | — | — | 1 | 7.34 |
| CHEMBL560502 | — | — | 1 | 7.27 |
| CHEMBL559830 | — | — | 1 | 7.16 |
| CHEMBL564880 | — | — | 1 | 7.04 |
| CHEMBL560702 | — | — | 1 | 7.02 |
| CHEMBL537958 | — | — | 1 | 7.01 |
| CHEMBL549882 | — | — | 1 | 6.92 |
| CHEMBL550083 | — | — | 1 | 6.82 |
| CHEMBL540217 | — | — | 1 | 6.77 |
| CHEMBL562228 | — | — | 1 | 6.77 |
| CHEMBL561644 | — | — | 1 | 6.70 |
| CHEMBL551038 | — | — | 1 | 6.58 |
| CHEMBL565059 | — | — | 1 | 6.52 |
| CHEMBL537959 | — | — | 1 | 6.40 |
| CHEMBL539445 | — | — | 1 | 6.22 |
| CHEMBL565218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565020 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL560502 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL559830 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL564880 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL560702 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL537958 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL549882 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL550083 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL540217 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL562228 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL561644 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL551038 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL565059 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL537959 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL539445 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL565218 | — | IC50 | - | — | - |