Assay Detail
Binding
CHEMBL1031977
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Inhibition of Bacillus cereus recombinant DHFR expressed in Escherichia coli BL21(DE3) assessed as enzyme-dependent NADPH consumption
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus cereus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.18 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560702 | — | — | 1 | 6.57 |
| CHEMBL550083 | — | — | 1 | 6.57 |
| CHEMBL551038 | — | — | 1 | 6.57 |
| CHEMBL561644 | — | — | 1 | 6.57 |
| CHEMBL565020 | — | — | 1 | 6.57 |
| CHEMBL565059 | — | — | 1 | 6.57 |
| CHEMBL549882 | — | — | 1 | 6.57 |
| CHEMBL562228 | — | — | 1 | 6.57 |
| CHEMBL560502 | — | — | 1 | 6.57 |
| CHEMBL565218 | — | — | 1 | 4.43 |
| CHEMBL564880 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560702 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL550083 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL551038 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL561644 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL565020 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL565059 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL549882 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL562228 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL560502 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL565218 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL564880 | — | IC50 | = | 37000.0 | nM | 4.43 |