Assay Detail
Functional
CHEMBL1032031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AtT |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.94 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 9.85 |
| CHEMBL556269 | — | — | 1 | 8.91 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273273 | 5-OH-DPAT | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL556269 | — | EC50 | = | 1.23 | nM | 8.91 |
| CHEMBL59 | DOPAMINE | EC50 | = | 8.53 | nM | 8.07 |