Assay Detail
Binding
CHEMBL1032134
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Inhibition of SphK2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.11 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67166 | SPHINGOSINE | — | 1 | 5.81 |
| CHEMBL561296 | — | — | 1 | 5.36 |
| CHEMBL551232 | — | — | 1 | 5.24 |
| CHEMBL551092 | — | — | 1 | 5.14 |
| CHEMBL561434 | — | — | 1 | 4.88 |
| CHEMBL561025 | — | — | 1 | 4.78 |
| CHEMBL559072 | — | — | 1 | 4.54 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67166 | SPHINGOSINE | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL561296 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL551232 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL551092 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL561434 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL561025 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL559072 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | IC50 | > | 80000.0 | nM | - |