Assay Detail
Binding
CHEMBL1032319
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Inhibition of human recombinant CDK5/p25 expressed in Escherichia coli
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.72 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522868 | — | — | 1 | 7.70 |
| CHEMBL495093 | — | — | 1 | 7.60 |
| CHEMBL523694 | — | — | 1 | 7.40 |
| CHEMBL521834 | — | — | 1 | 7.28 |
| CHEMBL409450 | 6BIO | — | 1 | 7.08 |
| CHEMBL493883 | — | — | 1 | 7.00 |
| CHEMBL494481 | — | — | 1 | 7.00 |
| CHEMBL521868 | — | — | 1 | 7.00 |
| CHEMBL1203920 | — | — | 1 | 7.00 |
| CHEMBL494685 | — | — | 1 | 6.89 |
| CHEMBL3216659 | — | — | 1 | 6.75 |
| CHEMBL523714 | — | — | 1 | 6.70 |
| CHEMBL522503 | — | — | 1 | 6.70 |
| CHEMBL3216892 | — | — | 1 | 6.70 |
| CHEMBL494663 | — | — | 1 | 6.68 |
| CHEMBL494867 | — | — | 1 | 6.62 |
| CHEMBL3216218 | — | — | 1 | 6.52 |
| CHEMBL493657 | — | — | 1 | 6.51 |
| CHEMBL3216893 | — | — | 1 | 6.48 |
| CHEMBL522537 | — | — | 1 | 6.40 |
| CHEMBL3215571 | — | — | 1 | 6.40 |
| CHEMBL493656 | — | — | 1 | 6.30 |
| CHEMBL493683 | — | — | 1 | 6.22 |
| CHEMBL492646 | — | — | 1 | 6.05 |
| CHEMBL494686 | — | — | 1 | 5.00 |
| CHEMBL525044 | — | — | 1 | - |
| CHEMBL523047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522868 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL495093 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL523694 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL521834 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL409450 | 6BIO | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL493883 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL494481 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL521868 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1203920 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL494685 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3216659 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL523714 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL522503 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3216892 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL494663 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL494867 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3216218 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL493657 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3216893 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL522537 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3215571 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL493656 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL493683 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL492646 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL494686 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL525044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL523047 | — | IC50 | > | 10000.0 | nM | - |