Assay Detail
Binding
CHEMBL1032320
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Inhibition of pig GSK3alpha/beta
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.56 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216659 | — | — | 1 | 8.89 |
| CHEMBL523714 | — | — | 1 | 8.48 |
| CHEMBL3216892 | — | — | 1 | 8.38 |
| CHEMBL409450 | 6BIO | — | 1 | 8.30 |
| CHEMBL3216218 | — | — | 1 | 8.30 |
| CHEMBL522537 | — | — | 1 | 8.15 |
| CHEMBL493656 | — | — | 1 | 7.96 |
| CHEMBL493657 | — | — | 1 | 7.85 |
| CHEMBL3215571 | — | — | 1 | 7.70 |
| CHEMBL1203920 | — | — | 1 | 7.64 |
| CHEMBL494685 | — | — | 1 | 7.58 |
| CHEMBL523694 | — | — | 1 | 7.57 |
| CHEMBL521834 | — | — | 1 | 7.54 |
| CHEMBL494686 | — | — | 1 | 7.52 |
| CHEMBL525044 | — | — | 1 | 7.52 |
| CHEMBL3216893 | — | — | 1 | 7.48 |
| CHEMBL494481 | — | — | 1 | 7.48 |
| CHEMBL495093 | — | — | 1 | 7.47 |
| CHEMBL522868 | — | — | 1 | 7.46 |
| CHEMBL494663 | — | — | 1 | 7.40 |
| CHEMBL521868 | — | — | 1 | 7.39 |
| CHEMBL493883 | — | — | 1 | 7.27 |
| CHEMBL493683 | — | — | 1 | 7.22 |
| CHEMBL494867 | — | — | 1 | 7.17 |
| CHEMBL492646 | — | — | 1 | 6.96 |
| CHEMBL523047 | — | — | 1 | 6.85 |
| CHEMBL522503 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216659 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL523714 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3216892 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL409450 | 6BIO | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3216218 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL522537 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL493656 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL493657 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3215571 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1203920 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL494685 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL523694 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL521834 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL494686 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL525044 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3216893 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL494481 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL495093 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL522868 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL494663 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL521868 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL493883 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL493683 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL494867 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL492646 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL523047 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL522503 | — | IC50 | = | 28000.0 | nM | 4.55 |